Radiation Therapy Mechanism

Radiation therapy or radiotherapy often abbreviated rt rtx or xrt is therapy using ionizing radiation generally as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. The application of these treatment modalities in specific malignancies and its integration with other treatment modalities are discussed in the treatment topics for those diseases.

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Following radiation therapy to the head for brain tumors more than 80 of patients who live six months at least after the treatment report a loss of some cognitive functions such as memory.

Radiation therapy mechanism. Ionizing radiation is used extensively to treat many different types of cancer. Cancer cells whose dna is damaged beyond repair stop dividing and die. Radiation therapy can kill cancer cells by a variety of mechanisms.

Recently we have better understood that components within the tumour microenvironment have pivotal roles in determining treatment outcomes. The results suggested that the patients receiving daily mmf treatment during rt might experience reduced acute dermal toxicity compared to the patients receiving placebo54 another randomized trial demonstrated that the preventive and sustained use of 01 methylprednisolone was better for relieving skin damage caused by radiation therapy than. Radiation induced secondary malignancy is another very serious adverse effect that has been reported.

Radiotherapy plays a central part in curing cancer. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body. For decades most research on improving treatment outcomes has focussed on modulating radiation induced biological effects on cancer cells.

Despite the use of chemotherapy radiation therapy and surgery the overall outcome for cancer cure continues to be disappointing. As there is no exit dose when using proton radiation therapy the dose to surrounding normal tissues can be significantly limited reducing the acute toxicity which positively impacts the risk for these long term side effects. In this topic the mechanism of action of radiation will be reviewed along with the key features of different rt modalities.

Radiation therapy offers an effective treatment for advanced cancer and the prime goal of radiation treatment is to inhibit the cancer cells multiplication potential and eventually kill the cells. Radiation therapy is a technique often used in the treatment of cancer particularly when the tumor is confined to a certain area in the body that can be physically targeted. Mechanism and resistance sanna ali march 22 2012 submitted as coursework for ph241 stanford university winter 2012 introduction.

The main goal of radiation therapy is to deprive cancer cells of their multiplication potential and eventually kill the cancer cells. However the mechanism of cell death response to irradiation is complex.

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